Decreased hippocampal mineralocorticoid / glucocorticoid receptor ratio is associated with low - birth 1 weight in female

نویسندگان

  • Shirlene X Ong
  • Keefe Chng
  • Michael J Meaney
  • Jan P Buschdorf
چکیده

Decreased hippocampal mineralocorticoid/glucocorticoid receptor ratio is associated with low-birth 1 weight in female Cynomolgus macaque neonates 2 3 Shirlene X Ong, Keefe Chng, Michael J Meaney , Jan P Buschdorf 4 Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), 5 Singapore, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Singapore 6 Sackler Program for Epigenetics and Psychobiology at McGill University, Douglas Mental Health 7 University Institute, 6875 LaSalle Boulevard, Montreal, (Quebec) H4H 1R3 Canada 8 9 Corresponding author and person to whom reprint requests should be addressed: 10 Jan P Buschdorf 11 Singapore Institute for Clinical Sciences 12 Brenner Centre for Molecular Medicine 13 30 Medical Drive 14 Singapore 117609 15 DID (65) 6407 0568 16 Fax (65) 67766840 17 [email protected] 18 19 MR/GR ratio associates with low birth weight 20 21

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Maternal glucocorticoid treatment programs HPA regulation in adult offspring: sex-specific effects.

Pregnant guinea pigs were treated with dexamethasone (1 mg/kg) or vehicle on days 40--41, days 50--51, and days 60--61 of gestation. Adult offspring were split into two groups. Group 1 guinea pigs were catheterized, and the hypothalamo-pituitary-adrenal (HPA) axis was tested in basal and activated states. Group 2 guinea pigs were euthanized with no further manipulation. In male offspring, prena...

متن کامل

Expressions of Hippocampal Mineralocorticoid Receptor (MR) and Glucocorticoid Receptor (GR) in the Single-Prolonged Stress-Rats

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience. Single-prolonged stress (SPS) is one of the animal models proposed for PTSD. Rats exposed to SPS showed enhanced inhibition of the hypothalamo-pituitary-adrenal (HPA) axis, which has been reliably reproduced in patients with PTSD. Mineralocorticoid receptor (MR) and glucocorticoid receptor ...

متن کامل

Spatial performance and corticosteroid receptor status in the 21-day restraint stress paradigm.

Twenty-one days of restraint stress has been shown to affect hippocampal plasticity, neurogenesis, and spatial memory. Hippocampal glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) are the main mediators of stress response and learning/memory processes. We studied the performance of male and female rats on a hippocampal-dependent spatial task after 21 days of restraint in relat...

متن کامل

استفاده از مواد اسپرم کش و غلبه بر حاملگی

The relation between periconceptional vaginal permicide use and sex ratio at birth, birth weight, and the frequency of congenital anomalies was examined in a cohort of 2,712 New York City obstetric patients, 149 of whom (5.5 per cent) became pregnant while using spermicides or had used spermicides before and after conception. Periconceptional spermicide use was not associated with any important...

متن کامل

Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin.

Abnormal interactions between serotonin (5-hydroxytryptamine) and glucocorticoids, notably in the hippocampus, may underpin neuroendocrine, affective and cognitive dysfunction in depression and ageing. Glucocorticoids act via intracellular glucocorticoid and mineralocorticoid receptors, whereas 5-hydroxytryptamine binds to a family of transmembrane sites; both cross- and auto-regulation have be...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013